Lipid Droplet Associated Proteins and Control of Triacylglycerol Metabolism

Lipid droplet-associated proteins in atherosclerosis (Review)

Accumulation of atherosclerotic plaques in arterial walls leads to major cardiovascular diseases and stroke. Macrophages/foam cells are central components of atherosclerotic plaques, which populate the arterial wall in order to remove harmful modified low‑density lipoprotein (LDL) particles, resulting in the accumulation of lipids, mostly LDL‑derived cholesterol ester, in cytosolic lipid drople...

Arabidopsis SEIPIN Proteins Modulate Triacylglycerol Accumulation and Influence Lipid Droplet Proliferation.

The lipodystrophy protein SEIPIN is important for lipid droplet (LD) biogenesis in human and yeast cells. In contrast with the single SEIPIN genes in humans and yeast, there are three SEIPIN homologs in Arabidopsis thaliana, designated SEIPIN1, SEIPIN2, and SEIPIN3. Essentially nothing is known about the functions of SEIPIN homologs in plants. Here, a yeast (Saccharomyces cerevisiae) SEIPIN del...

Control of hepatic triacylglycerol metabolism.

Avigan, J., Williams, C. D. & Blass, J. P. (1970) Biochim. Biophys. Acta 218,381-384 Betteridge, D. J., Higgins, M. J. P. & Galton, D. J. (1975) Br. Med. J . 4,5W502 Brown, M. S. & Goldstein, J. L. (1976) Science 191,150-154 Brown, M. S., Faust, J. R. & Goldstein (1975) J. Clin. Invest. 55, 783-793 Christophe, J. & Popjhk, G. (1961) J. Lipid Res. 2,244-257 Danielsson, H. (1972) Steroids 20,63-7...

Altered Lipid Droplet Dynamics in Hepatocytes Lacking Triacylglycerol Hydrolase Expression

Lipid droplets (LDs) form from the endoplasmic reticulum (ER) and grow in size by obtaining triacylglycerols (TG). Triacylglycerol hydrolase (TGH), a lipase residing in the ER, is involved in the mobilization of TG stored in LDs for the secretion of very-low-density lipoproteins. In this study, we investigated TGH-mediated changes in cytosolic LD dynamics. We have found that TGH deficiency resu...

Analysis of Lipid Droplet Proteins and their Contribution to Phospholipid Homeostasis during Lipid Droplet Expansion